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KMID : 0361120130270010015
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Korean Journal of Transplantation
2013 Volume.27 No. 1 p.15 ~ p.20
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A Case of Acute Graft versus Host Disease after Liver Transplantation
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Lee Hyun-Ji
Lee Sun-Min
Kim Byung-Chang
Chu Chong-Woo
Yang Kwang-Ho
Ryu Je-Ho
Moon Ki-Myung
Choi Kyung-Un
Kim Hyung-Hoi
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Abstract
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The mortality rate of patients with acute graft versus host disease (GVHD) after liver transplantation is very high. Autoimmune hepatitis and diabetes mellitus (DM) is the risk factors of GVHD. Human leukocyte antigen (HLA)-homozygote donor with one way donor-recipient HLA matching is on the risk of fatal GVHD following living donor liver transplantation (LDLT). If recipient has more than one risk factors of GVHD and is going to LDLT, HLA typing is needed to identify donor-dominant one-way HLA matching and helpful to diagnose and treat early and survival of patient will be improved. We report a case of GVHD after liver transplantation for hepatocellular carcinoma and DM who received an allograft from his HLA-homozygous son.
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KEYWORD
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Acute, Graft versus host disease, Liver transplantation, HLA antigens
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